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    Fibromyalgia treatment update: savella (milnacipran) approved; tricyclic antidepressants validated


    Two major pieces of news for people afflicted by fibromyalgia have appeared in the past few weeks; namely, the FDA approval of Savella (milnacipran), the third drug to receive federal backing for fibromyalgia, and the publication of a major meta-analysis in the prestigious Journal of the American Medical Association (JAMA), which confirmed that antidepressant medications (including Savella) can improve pain, depression, fatigue, sleep disturbances, and quality of life. Of note, however, is that the JAMA report also concluded that older medications, called tricyclic antidepressants, are most effective for treating fibromyalgia, even though they are not FDA approved for such use. It is often the case that older and now generic medications, such as the tricyclic antidepressant amitriptyline, ...

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